Journal article
Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives
Department of Systems Biology, Technical University of Denmark1
Network Engineering of Eukaryotic Cell Factories, Department of Systems Biology, Technical University of Denmark2
Symphogen A/S3
Novo Nordisk Foundation4
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5
CHO Cell Line Engineering and Design, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark6
Bioprocessing of the important Chinese hamster ovary (CHO) cell lines used for the production of biopharmaceuticals stands at the brink of several redefining events. In 2011, the field entered the genomics era, which has accelerated omics-based phenotyping of the cell lines. In this review we describe one possible application of this data: the generation of computational models for predictive and descriptive analysis of CHO cellular metabolism.
We describe relevant advances in other organisms and how they can be applied to CHO cells. The immediate implications of the implementation of these methods will be accelerated development of the next generation of CHO cell lines and derived biopharmaceuticals.
Language: | English |
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Year: | 2014 |
Pages: | 437-448 |
ISSN: | 20489153 and 20489145 |
Types: | Journal article |
DOI: | 10.4155/PBP.14.54 |
ORCIDs: | Fan, Yuzhou , Kildegaard, Helene Faustrup and Andersen, Mikael Rørdam |