Journal article
Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity.
Recent studies suggest that in the animal lineage one of the brogenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
Language: | English |
---|---|
Year: | 2004 |
Pages: | 3-6 |
ISSN: | 18733468 and 00145793 |
Types: | Journal article |
DOI: | 10.1016/S0014-5793(04)00081-X |
Amino Acid Sequence Animals Conserved Sequence DNA Deoxyribonucleoside kinase Evolution Evolution, Molecular Gene duplication Molecular Sequence Data Nucleic Acid Precursors Nucleic acid precursor Phosphorylation Phosphotransferases (Alcohol Group Acceptor) Phylogeny Point Mutation Sequence Homology, Amino Acid Structure-Activity Relationship Substrate Specificity Substrate specificity deoxyribonucleoside kinases