Conference paper
Nanoscaled biological gated field effect transistors for cytogenetic analysis
Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors (FET) is presented here.
The FET is gated by the hybridization of the target DNA on the semiconducting nanowire. The results show an extreme sensitivity to the hybridization process, so that the hybridization and dehybridisation can be followed in real time. The nanoscaled FET is made of polysilicon using standard UV lithography enabling batch processing of the sensors.
Language: | English |
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Publisher: | IEEE |
Year: | 2014 |
Pages: | 130-134 |
Proceedings: | 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems |
ISBN: | 1479947253 , 1479947261 , 9781479947256 and 9781479947263 |
Types: | Conference paper |
DOI: | 10.1109/NEMS.2014.6908775 |
ORCIDs: | Dimaki, Maria and Svendsen, Winnie Edith |
Biological cells Biosensors DNA DNA biosensor Impedance Peptides Probes Silicon cancer cancer diagnosis cancer onset cellular biophysics chromosomal translocation analysis chromosome abnormalities chromosome function chromosome structure chromosome translocations cytogenetic analysis dehybridisation field effect transistors genetics genomics hybridization process label free detection method nanomedicine nanoscaled FET nanoscaled biological gated field effect transistors nanowires patient diagnosis polysilicon semiconducting nanowire sensor batch processing silicon nanowires standard UV lithography target DNA