Conference paper
Whole genome sequencing for childhood cancer in Denmark
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark1
Functional Human Variation, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark2
Department of Bio and Health Informatics, Technical University of Denmark3
Disease Intelligence and Molecular Evolution, Department of Bio and Health Informatics, Technical University of Denmark4
The talk will describe our involvement in the Danish project STAGING, “Sequencing Three Actionable Genomes – Implications & National Guidelines”, an interdisciplinary, multi-tiered 3-year study of 600 consecutive childhood cancer patients and their families, with extensive genomic sequencing of host, tumour and gut microbiome’s genomes.
In Europe, cancer accounts for approximately 25% of all deaths in children >1 year. Most cured patients are burdened by late effects, including risk of second cancer and debilitating toxicities. Recent advancements in genetic sequencing technology and reduction in costs have led to new strategies for identification of cancer predisposition and targeted treatment.
STAGING is a nation-wide programme offering full, up-front genetic testing for childhood cancer patients and implements the findings into health care. Paediatric oncology provides a unique proof- of-principle framework for such a program, since it is one of the best organized medical specialties with nation-wide strategies for diagnostics, therapy, deep response phenotyping, and follow-up.
| Language: | English |
|---|---|
| Year: | 2016 |
| Proceedings: | Sustain-ATV Conference 2016 |
| Types: | Conference paper |
| ORCIDs: | Gupta, Ramneek |
