Conference paper
Single nucleotide polymorphism (SNP) detection on a magnetoresistive sensor
Department of Micro- and Nanotechnology, Technical University of Denmark1
Magnetic Systems, Department of Micro- and Nanotechnology, Technical University of Denmark2
Fluidic Array Systems and Technology, Department of Micro- and Nanotechnology, Technical University of Denmark3
Department of Physics, Technical University of Denmark4
We present a magnetoresistive sensor platform for hybridization assays and demonstrate its applicability on single nucleotide polymorphism (SNP) genotyping. The sensor relies on anisotropic magnetoresistance in a new geometry with a local negative reference and uses the magnetic field from the sensor bias current to magnetize magnetic beads in the vicinity of the sensor.
The method allows for real-time measurements of the specific bead binding to the sensor surface during DNA hybridization and washing. Compared to other magnetic biosensing platforms, our approach eliminates the need for external electromagnets and thus allows for miniaturization of the sensor platform.
Language: | English |
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Publisher: | Chemical and Biological Microsystems Society |
Year: | 2013 |
Pages: | 1523-1525 |
Proceedings: | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
ISBN: | 0979806461 and 9780979806469 |
Types: | Conference paper |
ORCIDs: | Dufva, Martin and Hansen, Mikkel Fougt |