Journal article
Enhancing the signal-to-noise ratio in ophthalmic optical coherence tomography by image registration—method and clinical examples
Optical Diagnostics and Information Processing, Optics and Plasma Research Department, Risø National Laboratory for Sustainable Energy, Technical University of Denmark1
Optics and Plasma Research Department, Risø National Laboratory for Sustainable Energy, Technical University of Denmark2
Risø National Laboratory for Sustainable Energy, Technical University of Denmark3
Optical coherence tomography (OCT) has already proven an important clinical tool for imaging and diagnosing retinal diseases. Concerning the standard commercial ophthalmic OCT systems, speckle noise is a limiting factor with respect to resolving relevant retinal features. We demonstrate successful suppression of speckle noise from mutually aligning a series of in vivo OCT recordings obtained from the same retinal target using the Stratus system from Humphrey-Zeiss.
Our registration technique is able to account for the axial movements experienced during recording as well as small transverse movements of the scan line from one scan to the next. The algorithm is based on a regularized shortest path formulation for a directed graph on a map formed by interimage (B-scan) correlations.
The resulting image enhancement typically increases the contrast-to-noise ratio (CNR) with a factor of three or more and facilitates segmentation and quantitative characterization of pathologies. The method is currently successfully being applied by medical doctors in a number of specific retinal case studies.
Language: | English |
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Publisher: | SPIE-Intl Soc Optical Eng |
Year: | 2007 |
Pages: | 041208 |
ISSN: | 10833668 and 15602281 |
Types: | Journal article |
DOI: | 10.1117/1.2772879 |
ORCIDs: | Jørgensen, Thomas Martini |
Algorithms Humans Image Enhancement Image Interpretation, Computer-Assisted Pattern Recognition, Automated Reproducibility of Results Retina Retinal Diseases Retinoscopy Sensitivity and Specificity Subtraction Technique Tomography, Optical Coherence biomedical optical imaging directed graphs diseases eye image denoising image enhancement image registration image segmentation macular hole medical image processing optical coherence tomography (OCT) optical tomography regularized dynamic programming speckle speckle reduction