Journal article
Chemistry and Biology of Natural Azoxy Compounds
Center for Microbial Secondary Metabolites, Centers, Technical University of Denmark1
Natural Product Discovery, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark2
Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark3
Department of Biotechnology and Biomedicine, Technical University of Denmark4
DTU Metabolomics Core, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark5
Azoxy compounds belong to a small yet intriguing group of natural products sharing a common functional group with the general structure RN═N+(O–)R. Their intriguing chemical structures, diverse biological activities, and important industrial applications have received attention from researchers in natural product chemistry, total synthesis, and biosynthesis.
This review presents current updates about the structural diversity of natural azoxy compounds isolated from different organisms and highlights the enzymes and biological logic involved in their construction. We assume that the identification of key enzymes will provide efficient tools in biocatalysis to generate new azoxy compounds, while genome mining may result in novel natural azoxy compounds of medical and industrial interest.
Language: | English |
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Publisher: | American Chemical Society and American Society of Pharmacognosy |
Year: | 2020 |
Pages: | 3482-3491 |
ISSN: | 15206025 and 01633864 |
Types: | Journal article |
DOI: | 10.1021/acs.jnatprod.0c00725 |
ORCIDs: | Wibowo, Mario and Ding, Ling |