Journal article
Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
Tropical Pharmacology and Biotherapeutics, Section for Protein Science and Biotherapeutics, Department of Biotechnology and Biomedicine, Technical University of Denmark1
Department of Biotechnology and Biomedicine, Technical University of Denmark2
Protease Network Degradomics, Section for Protein Science and Biotherapeutics, Department of Biotechnology and Biomedicine, Technical University of Denmark3
University of São Paulo4
Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays.
Similar findings in vivo could have clinical implications for snakebite management and require further examination.
| Language: | English |
|---|---|
| Publisher: | MDPI AG |
| Year: | 2020 |
| Pages: | 240 |
| ISSN: | 20726651 |
| Types: | Journal article |
| DOI: | 10.3390/toxins12040240 |
| ORCIDs: | Knudsen, Cecilie , auf dem Keller, Ulrich , Kalogeropoulos, Konstantinos , 0000-0002-6712-6033 , 0000-0001-6540-2295 , Laustsen, Andreas H. and Sørensen, Christoffer V. |
