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Conference paper

Efficient Computation of the Continuous-Discrete Extended Kalman Filter Sensitivities Applied to Maximum Likelihood Estimation

From

Department of Applied Mathematics and Computer Science, Technical University of Denmark1

Scientific Computing, Department of Applied Mathematics and Computer Science, Technical University of Denmark2

Dynamical Systems, Department of Applied Mathematics and Computer Science, Technical University of Denmark3

In this paper, we present and compare different methods for computing the likelihood function and its gradient. We consider nonlinear continuous-discrete models described by a system of stochastic differential equations (SDEs) with discrete-time measurements. The problem of maximum likelihood estimation (MLE) is formulated as a nonlinear program (NLP) and it is solved numerically using a gradient-based single shooting algorithm.

The estimates of the mean and its covariance are computed using a continuous-discrete extended Kalman filter (CDEKF). We derive analytical expressions for the gradient of the likelihood function. We discuss some aspects of the implementation of MLE for non-stiff systems. In particular, we present an efficient way of computing the state covariance matrix and its gradient using explicit Runge-Kutta schemes.

We verify our implementation using a numerical example related to type 1 diabetes and demonstrate how to apply it for nonlinear parameter estimation.

Language: English
Publisher: IEEE
Year: 2019
Pages: 6983-6988
Proceedings: 58th IEEE Conference on Decision and Control
ISBN: 1728113970 , 1728113989 , 1728113997 , 9781728113975 , 9781728113982 and 9781728113999
ISSN: 25762370 and 07431546
Types: Conference paper
DOI: 10.1109/cdc40024.2019.9029672
ORCIDs: Boiroux, Dimitri , Ritschel, Tobias Kasper Skovborg , Poulsen, Niels Kjølstad , Madsen, Henrik and Jørgensen, John Bagterp

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