Journal article
A remote but significant sequence homology between glycoside hydrolase clan GH-H and glycoside hydrolase family GH 31
Although both the α-amylase super-family, i.e. the glycoside hydrolase (GH) clan GH-H (the GH families 13, 70 and 77), and family GH31 share some characteristics, their different catalytic machinery prevents classification of GH31 in clan GH-H. A significant but remote evolutionary relatedness is, however, proposed for clan GH-H with GH31.
A sequence alignment, based on the idea that residues equivalent in the primordial catalytic GH-H/GH31 (β/α)8-barrel may not be found in the present-day GH-H and GH31 structures at strictly equivalent positions, shows remote sequence homologies covering β3, β4, β7 and β8 of the GH-H and GH31 (β/α)8-barrels.
Structure comparison of GH13 α-amylase and GH31 α-xylosidase guided alignment of GH-H and GH31 members for construction of evolutionary trees. The closest sequence relationship displayed by GH31 is to GH77 of clan GH-H.
Language: | English |
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Year: | 2007 |
Pages: | 1261-1268 |
ISSN: | 18733468 and 00145793 |
Types: | Journal article |
DOI: | 10.1016/j.febslet.2007.02.036 |
ORCIDs: | Svensson, Birte |