Journal article
Structural basis for cyclophellitol inhibition of a β-glucosidase
In
Organic and Biomolecular Chemistry
—
2007, Volume 5, Issue 3, pp. 444-446
Abstract
The structural basis for b-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry. The natural product was shown to bind by a covalent bond in the active site of the enzyme. This bond is formed by ring-opening of the epoxide in cyclophellitol with a carboxylic acid from the enzyme.
| Language: | English |
|---|---|
| Publisher: | The Royal Society of Chemistry |
| Year: | 2007 |
| Pages: | 444-446 |
| ISSN: | 14770539 and 14770520 |
| Types: | Journal article |
| DOI: | 10.1039/b616590g |
| ORCIDs: | Madsen, Robert |
