Journal article
Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs
Microbial Ecology, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark1
Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark2
National Veterinary Institute, Technical University of Denmark3
Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs.
Methods : Piglets were delivered by cesarean section at 92% gestation, reared in infant incubators, and fed infant formula or colostrum every 3 hours (n = 120) until tissue collection at 1-2 days of age. Results: Clinical and histopathologic signs of NEC were observed in 57% of pigs fed FORMULA (26/46) and in 5% of pigs fed COLOSTRUM (2/38) (P
| Language: | English |
|---|---|
| Year: | 2006 |
| Pages: | 1776-1792 |
| ISSN: | 10486771 , 15280012 and 00165085 |
| Types: | Journal article |
| DOI: | 10.1053/j.gastro.2006.02.026 |
| ORCIDs: | Boye, Mette , 0000-0002-2876-1667 , 0000-0001-7480-6064 , 0000-0003-1575-2507 and 0000-0001-6853-3805 |
Animals Animals, Newborn Base Sequence Biopsy, Needle Causality Colony Count, Microbial Colostrum DNA, Bacterial Enterocolitis, Necrotizing Female Gastrointestinal Tract Immunohistochemistry Infant Formula Intestinal Absorption Intestinal Mucosa Intestine, Small Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy, Animal Premature Birth Probability Risk Factors Sensitivity and Specificity Swine
