Journal article
A Four‐Component Reaction for the Synthesis of Dioxadiazaborocines
A four‐component reaction for the synthesis of heterocyclic boronates is reported. Readily available hydrazides, α‐hydroxy aldehydes, and two orthogonally reactive boronic acids are combined in a single step to give structurally distinct bicyclic boronates, termed dioxadiazaborocines (DODA borocines).
In this remarkable process, one boronic acid reacts as a carbon nucleophile and the other as a boron electrophile to provide enantio‐ and diastereomerically pure heterocyclic boronates with multiple stereocenters in high yields.
Language: | English |
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Publisher: | WILEY‐VCH Verlag |
Year: | 2015 |
Pages: | 8515-8517 |
ISSN: | 00448249 , 15213757 , 15213773 and 14337851 |
Types: | Journal article |
DOI: | 10.1002/ange.201502989 |