Journal article
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment.
The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
| Language: | English |
|---|---|
| Publisher: | American Association for the Advancement of Science |
| Year: | 2007 |
| Pages: | 207-12 |
| ISSN: | 10959203 and 00368075 |
| Types: | Journal article |
| DOI: | 10.1126/science.1132894 |
Animals Biological Transport DNA Transposable Elements DNA, Protozoan Gene Transfer, Horizontal Genes, Protozoan Genome, Protozoan Humans Hydrogen Metabolic Networks and Pathways Molecular Sequence Data Multigene Family Organelles Oxidative Stress Peptide Hydrolases Protozoan Proteins RNA Processing, Post-Transcriptional Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Sexually Transmitted Diseases Trichomonas Infections Trichomonas vaginalis
