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Journal article

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

In Science 2019, Volume 366, Issue 6472, pp. eaax9198-eaax9198
From

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark1

High Throughput Molecular Bioscience, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2

KTH Royal Institute of Technology3

Karolinska Institutet4

Uppsala University5

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types.

All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

Language: English
Publisher: American Association for the Advancement of Science
Year: 2019
Pages: eaax9198-eaax9198
ISSN: 10959203 and 00368075
Types: Journal article
DOI: 10.1126/science.aax9198
ORCIDs: 0000-0002-4858-8056 , 0000-0002-7000-4416 , 0000-0002-7422-6104 , 0000-0002-8901-2678 , 0000-0003-3932-788X , 0000-0002-9941-7855 , 0000-0001-7256-5770 , 0000-0002-5248-8568 , 0000-0002-0017-7987 , 0000-0003-0996-1644 , 0000-0002-4254-6090 , 0000-0002-3721-8586 , 0000-0002-0257-7554 , 0000-0003-3717-5018 , 0000-0002-0327-7377 , 0000-0001-8947-2562 , 0000-0003-3014-5502 , 0000-0002-0064-4776 , 0000-0003-0703-3940 , 0000-0001-5611-1015 , 0000-0001-8800-8469 and 0000-0003-0198-7137

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