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Conference paper

Static analysis of a Model of the LDL degradation pathway

In Third International Workshop on Computational Methods in Systems Biology (cmsb'05) — 2005

By Pilegaard, Henrik1; Nielson, Flemming1,2; Nielson, Hanne Riis1,2

From

Department of Informatics and Mathematical Modeling, Technical University of Denmark1

Computer Science and Engineering, Department of Informatics and Mathematical Modeling, Technical University of Denmark2

BioAmbients is a derivative of mobile ambients that has shown promise of describing interesting features of the behaviour of biological systems. As for other ambient calculi static program analysis can be used to compute safe approximations of the behavior of modelled systems. We use these tools to model and analyse the production of cholesterol in living cells and show that we are able to pinpoint the difference in behaviour between models of healthy systems and models of mutated systems giving rise to known diseases.

Language: English
Publisher: University of Edinburgh
Year: 2005
Types: Conference paper
ORCIDs: Nielson, Flemming and Nielson, Hanne Riis
Keywords

LDL degradation biological pathway static analysis systems biology

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