Journal article
Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana
Department of Plant Biology and Biotechnology, Copenhagen Plant Science Centre, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark
Four novel geminally dialkylated, non-aromatic acetophenone derivatives 1–4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A–C, where Coodeanone B was found in both E and Z configuration of the 6′‴–7′‴ double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (4) was found to have activity toward Plasmodium falciparum (malaria) (IC50=42.8μM).
Language: | English |
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Year: | 2012 |
Pages: | 371-375 |
ISSN: | 18767486 and 18743900 |
Types: | Journal article |
DOI: | 10.1016/j.phytol.2012.03.005 |
ORCIDs: | Simonsen, Henrik Toft |