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Conference paper

Role of Snf3 in glucose homeostasis of Saccharomyces cerevisiae (review)

By Kielland-Brandt, Morten1,2

From

Department of Systems Biology, Technical University of Denmark1

Eucaryotic Molecular Cell Biology, Department of Systems Biology, Technical University of Denmark2

The non-transporting, transporter-like molecular tasting devices Snf3 (1) and Ssy1 (2,3,4,5) help yeast increase amounts of relevant permeases in response to extracellular nutrients. On the other hand, conditions that enhance intracellular concentrations of same nutrients influence the involved signal pathways in directions opposite to those caused by extracellular nutrients (6,7), a phenomenon predicted to contribute to intracellular nutrient homeostasis.

Although significant, the influence of intracellular leucine on signaling from Ssy1 is relatively modest (6), whereas the conditions with enhanced intracellular glucose concentrations (7) caused a strong decrease in signaling from Snf3, suggesting an important role of Snf3 in intracellular glucose homeostasis.

Strategies for studies of this role will be discussed.

Language: English
Year: 2013
Proceedings: 31st Small Meeting on Yeast Transport and Energetics
Types: Conference paper
ORCIDs: Kielland-Brandt, Morten

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