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title:(Modelling AND the AND glucose-insulin-glucagon AND dynamics AND after AND subcutaneous AND administration AND of AND native AND glucagon AND and AND a AND novel AND glucagon AND analogue AND in AND dogs)
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Conference paper
Year: 2016
Language: English
2
Conference paper
Zealand Pharma has invented a glucagon analogue, ZP-GA-1, with increased stability in liquid formulation for treatment of hypoglycemia. A pharmacodynamic (PD) model is needed to compare ZP-GA-1 with marketed glucagon. We aim to develop a model of the complex glucose-insulin-glucagon dynamics based
Year: 2016
Language: English
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Report
satisfactorily for both glucagon and the analogue. Parameter estimates of the PD model were not significantly different between the two compounds. Conclusions The new PK/PD model enables simulations of the glucose-insulin-glucagon dynamics after a SC bolus of glucagon or glucagon analogue. The novel glucagon
Year: 2016
Language: English
