Journal article
Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones
In
Organic Letters
—
2006, Volume 8, Issue 10, pp. 2103-2106
Abstract
Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.
| Language: | English |
|---|---|
| Year: | 2006 |
| Pages: | 2103-2106 |
| ISSN: | 15237052 and 15237060 |
| Types: | Journal article |
| DOI: | 10.1021/ol060500i |
