Journal article
Separation enhancement in pinched flow fractionation
NSE-Optofluidics Group, NanoSystemsEngineering Section, Department of Micro- and Nanotechnology, Technical University of Denmark1
NanoSystemsEngineering Section, Department of Micro- and Nanotechnology, Technical University of Denmark2
Department of Micro- and Nanotechnology, Technical University of Denmark3
A method for enhancing the separation in the microfluidic size separation technique called pinched flow fractionation (PFF) is demonstrated experimentally and analyzed by numerical calculations. The enhancement is caused by a geometrical modification of the original PFF design. Seven different polystyrene bead sizes ranging from 0.25 to 2.5 mu m in radius were separated in a PFF and in an enhanced PFF device.
The separation in the two types of devices were compared and an amplification in the separation of up to 70% was achieved. Numerical calculations, which include an edge effect, are used to analyze the device.
| Language: | English |
|---|---|
| Publisher: | American Institute of Physics |
| Year: | 2008 |
| ISSN: | 10773118 and 00036951 |
| Types: | Journal article |
| DOI: | 10.1063/1.3028652 |
| ORCIDs: | Kristensen, Anders |
