Journal article
Synthesis of a Natural Product-Like Compound Collection through Oxidative Cleavage and Cyclization of Linear Peptides
Massive efforts in molecular library synthesis have strived for the development of synthesis methodology which systematically delivers natural product-like compounds of high spatial complexity. Herein, we present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions.
By harnessing the structural side-chain diversity and inherent stereochemical features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochem- ically diverse compounds was generated, and selected com- pounds were elaborated into isoform-selective metalloprotease inhibitors.
Language: | English |
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Publisher: | WILEY‐VCH Verlag |
Year: | 2014 |
Pages: | 11778-11782 |
ISSN: | 15213773 , 14337851 , 15213757 and 00448249 |
Types: | Journal article |
DOI: | 10.1002/anie.201405747 |