Journal article
N-Acyliminium Intermediates in Solid-Phase Synthesis
N-Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution-phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid-phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N-acyliminitun intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules.
Language: | English |
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Publisher: | Wiley Subscription Services, Inc., A Wiley Company |
Year: | 2010 |
Pages: | 242-256 |
ISSN: | 10970282 and 00063525 |
Types: | Journal article |
DOI: | 10.1002/bip.21358 |