Dataset
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Abstract
Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p
| Year: | 2017 |
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| Types: | Dataset |
| DOI: | 10.1371/journal.pgen.1006706 |
Keywords
25 trans-acting loci 79 loci 83 plasma protein biomarkers Biochemistry Biological Sciences not elsewhere classified CVD risk factors Chemical Sciences not elsewhere classified GWA study data Genetics Immunology Infectious Diseases Medicine Molecular Biology RANK-RANK association matrix metalloproteinase 9 plasma proteins regulation
