Journal article
Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B
Department of Systems Biology, Technical University of Denmark1
German Cancer Research Center2
Natural Product Chemistry, Department of Systems Biology, Technical University of Denmark3
Department of Chemistry, Technical University of Denmark4
Organic Chemistry, Department of Chemistry, Technical University of Denmark5
Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS).
Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
Language: | English |
---|---|
Publisher: | MDPI |
Year: | 2014 |
Pages: | 9786-9797 |
ISSN: | 14203049 and 14315157 |
Types: | Journal article |
DOI: | 10.3390/molecules19079786 |
ORCIDs: | Frisvad, Jens Christian , Gotfredsen, Charlotte Held and Larsen, Thomas Ostenfeld |