Journal article
Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide
In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively.
The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability.
The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.
| Language: | English |
|---|---|
| Year: | 2014 |
| Pages: | 37-44 |
| ISSN: | 18730191 and 09284931 |
| Types: | Journal article |
| DOI: | 10.1016/j.msec.2014.08.070 |
| ORCIDs: | Chronakis, Ioannis S. |
Animals Biomaterials Cadmium Compounds Cell Line Cell Survival Composite materials Ethers Fullerenes Mice Microscopy, Electron, Transmission Microscopy, Fluorescence Nanospheres Nitric Oxide Particle Size Quantum Dots Selenium Compounds Spectrometry, Fluorescence Surface properties cadmium selenide
