Journal article
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
National Food Institute, Technical University of Denmark1
DTU Multi Assay Core, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark2
Bispebjerg University Hospital3
Metagenomics, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark4
Research Group for Gut Microbiology and Immunology, National Food Institute, Technical University of Denmark5
Department of Systems Biology, Technical University of Denmark6
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark7
Functional Human Variation, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark8
Department of Bio and Health Informatics, Technical University of Denmark9
Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark10
Division of Food Microbiology, National Food Institute, Technical University of Denmark11
University of Copenhagen12
...and 2 moreLittle is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism.
We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa.
Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.
| Language: | English |
|---|---|
| Publisher: | Nature Publishing Group |
| Year: | 2016 |
| Pages: | 16093 |
| ISSN: | 20585276 |
| Types: | Journal article |
| DOI: | 10.1038/nmicrobiol.2016.93 |
| ORCIDs: | Roager, Henrik Munch , 0000-0002-6555-2557 , 0000-0003-3090-269X , Licht, Tine Rask , 0000-0001-8748-3831 , 0000-0002-3321-3972 , 0000-0001-7184-5949 , 0000-0002-0065-8174 , Bahl, Martin Iain , Frandsen, Henrik Lauritz , Nielsen, Henrik Bjørn and Gupta, Ramneek |
