Journal article
MicroRNA 486-3P as a stability marker in acute coronary syndrome
Bispebjerg University Hospital1
Department of Systems Biology, Technical University of Denmark2
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3
Integrative Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark4
Karolinska University Hospital5
Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers.
Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).
Language: | English |
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Publisher: | Portland Press Ltd. |
Year: | 2016 |
Pages: | e00351-e00351 |
ISSN: | 15734935 and 01448463 |
Types: | Journal article |
DOI: | 10.1042/BSR20160023 |
ORCIDs: | Folkersen, Lasse |