Journal article
Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin
National Food Institute, Technical University of Denmark1
Research Group for Global Capacity Building, National Food Institute, Technical University of Denmark2
Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark3
University of Bucharest4
European Food Safety Authority5
United States Food and Drug Administration6
Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.
| Language: | English |
|---|---|
| Publisher: | Oxford University Press |
| Year: | 2021 |
| Pages: | 3063-3065 |
| ISSN: | 14602091 and 03057453 |
| Types: | Journal article |
| DOI: | 10.1093/jac/dkab285 |
| ORCIDs: | Bortolaia, Valeria , Ronco, Troels , Leekitcharoenphon, Pimlapas , Kjeldgaard, Jette S. , Svendsen, Christina A. and Hendriksen, René S. |
