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Journal article

How compelling are the data for Epstein-Barr virus being a trigger for systemic lupus and other autoimmune diseases?

By Draborg, Anette1; Gonzalez-Izarzugaza, Jose Maria2,3,4; Houen, Gunnar1

From

Statens Serum Institut1

Department of Systems Biology, Technical University of Denmark2

Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3

Integrative Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark4

Systemic lupus erythematosus (SLE) is caused by a combination of genetic and acquired immunodeficiencies and environmental factors including infections. An association with Epstein-Barr virus (EBV) has been established by numerous studies over the past decades. Here, we review recent experimental studies on EBV, and present our integrated theory of SLE development.

Language: English
Year: 2016
Pages: 398-404
ISSN: 15316963 , 10408711 and 10808175
Types: Journal article
DOI: 10.1097/BOR.0000000000000289
ORCIDs: Gonzalez-Izarzugaza, Jose Maria
Keywords

EBV Immuno-deficiencies Infections SLE

Other keywords

Arthritis, Rheumatoid Autoimmune Diseases Epstein-Barr Virus Infections Evidence-Based Medicine Herpesvirus 4, Human Humans Lupus Erythematosus, Systemic Sjogren's Syndrome Virus Activation

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