Journal article
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
University of Padua1
Chester Beatty Laboratories2
University of Belgrade3
Swiss Institute of Bioinformatics4
University of Maryland School of Medicine5
Fundación Instituto Leloir6
Peter Pazmany Catholic University7
Danish Cancer Society8
Aix-Marseille Université9
University of Porto10
Universidad Nacional de Quilmes11
European Molecular Biology Laboratory12
Aristotle University of Thessaloniki13
Department of Health Technology, Technical University of Denmark14
Bioinformatics, Department of Health Technology, Technical University of Denmark15
Cancer Systems Biology, Bioinformatics, Department of Health Technology, Technical University of Denmark16
University of Cyprus17
Charles University18
European Bioinformatics Institute19
Research Centre for Natural Sciences20
Universidad Nacional de San Martin21
Eotvos Lorand University22
Vrije Universiteit Brussel23
Autonomous University of Barcelona24
Stockholm University25
Centre for Research and Technology Thessaly26
...and 16 moreThe Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%.
Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts.
Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
