Journal article
Radio frequency coils for hyperpolarized 13C magnetic resonance experiments with a 3T mr clinical scanner: Experience from a cardiovascular lab
National Research Council of Italy1
GE Healthcare2
Department of Health Technology, Technical University of Denmark3
Magnetic Resonance, Department of Health Technology, Technical University of Denmark4
Hyperpolarization & Metabolism, Magnetic Resonance, Department of Health Technology, Technical University of Denmark5
Center for Hyperpolarization in Magnetic Resonance, Centers, Technical University of Denmark6
Hyperpolarized 13C magnetic resonance (MR) is a promising technique for the noninvasive assessment of the regional cardiac metabolism since it permits heart physiology studies in pig and mouse models. The main objective of the present study is to resume the work carried out at our electromagnetic laboratory in the field of radio frequency (RF) coil design, building, and testing.
In this paper, first, we review the principles of RF coils, coil performance parameters, and estimation methods by using simulations, workbench, and MR imaging experiments. Then, we describe the simulation, design, and testing of different 13C coil configurations and acquisition settings for hyperpolarized studies on pig and mouse heart with a clinical 3T MRI scanner.
The coil simulation is performed by developing a signal-to-noise ratio (SNR) model in terms of coil resistance, sample-induced resistance, and magnetic field pattern. Coil resistance was calculated from Ohm’s law and sample-induced resistances were estimated with a finite-difference time-domain (FDTD) algorithm.
In contrast, the magnetic field per unit current was calculated by magnetostatic theory and a FDTD algorithm. The information could be of interest to graduate students and researchers working on the design and development of an MR coil to be used in 13C studies.
Language: | English |
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Publisher: | MDPI AG |
Year: | 2021 |
Pages: | 366 |
ISSN: | 20799292 |
Types: | Journal article |
DOI: | 10.3390/electronics10040366 |
ORCIDs: | 0000-0002-4317-4161 , 0000-0002-4486-8878 , 0000-0001-8332-7006 , 0000-0001-6955-9572 , 0000-0002-1334-1264 , Ardenkjaer-Larsen, Jan Henrik and 0000-0001-9042-340X |
Electronics TK7800-8360 magnetic resonance radio frequency coils simulation