Journal article
In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe2O3) Nanorods
National Institute of Technology Srinagar1
King Saud University2
Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark3
Targeted Radionuclides, Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark4
Medical Isotopes, Hevesy and Dosimetry, Department of Health Technology, Technical University of Denmark5
Department of Health Technology, Technical University of Denmark6
Herein we report synthesis of hematite (α-Fe2O3) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials.
As we know that Fe2O3 nanorods with size in the range of 25–30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T2 MR imaging contrast agents. An excellent T2 MRI contrast of 38.763 mM–1s–1 achieved which is highest reported so far for α-Fe2O3. Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent.
Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T2 MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods.
| Language: | English |
|---|---|
| Publisher: | Springer US |
| Year: | 2022 |
| Pages: | 10 |
| ISSN: | 15734838 and 09574530 |
| Types: | Journal article |
| DOI: | 10.1007/s10856-021-06636-1 |
| ORCIDs: | 0000-0002-2794-3872 |
Animals Biocompatible Materials Cell Line Cell Survival Female Ferric Compounds HeLa Cells Humans In Vitro Techniques Magnetic Resonance Imaging Materials Testing Materials of engineering and construction. Mechanics of materials Medical technology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Microscopy, Electron, Scanning Nanotubes Neoplasms, Experimental Phototherapy Polyethylene Glycols R855-855.5 Spectrum Analysis, Raman TA401-492 X-Ray Diffraction ferric oxide
