Journal article
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors
Interdisciplinary Nanoscience Center (iNANO), Departments of Molecular Biology, Physics and Astronomy, Aarhus University, DK-8000 Aarhus C, Denmark.1
Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG).
Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333-20,000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (M(w)) PEG molecules.
By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating M(w) of 10,000 Da.
| Language: | English |
|---|---|
| Year: | 2012 |
| Pages: | 2352-2361 |
| ISSN: | 20403372 and 20403364 |
| Types: | Journal article |
| DOI: | 10.1039/c2nr11554a |
| ORCIDs: | Nielsen, Niels Chr and Kjems, Jørgen |
Animals Cell Line, Tumor Coated Materials, Biocompatible Contrast Media Drug Delivery Systems Ferric Compounds Magnetics Metal Nanoparticles Mice Mice, Inbred C3H Models, Biological Molecular Weight Neoplasms Oleic Acid Particle Size Polyethylene Glycols Silanes Tissue Distribution ferric oxide
