Journal article
Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients
Rigshospitalet1
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Department of Systems Biology, Technical University of Denmark4
Infection Microbiology, Department of Systems Biology, Technical University of Denmark5
The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment.
Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.
Language: | English |
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Year: | 2015 |
Pages: | 599-611 |
ISSN: | 17460921 and 17460913 |
Types: | Journal article |
DOI: | 10.2217/FMB.15.3 |
ORCIDs: | Madsen Sommer, Lea Mette , Jelsbak, Lars and Molin, Søren |