Journal article
Cerebrospinal fluid influx drives acute ischemic tissue swelling
University of Rochester1
University of Copenhagen2
Disease Intelligence and Molecular Evolution, Department of Bio and Health Informatics, Technical University of Denmark3
Department of Bio and Health Informatics, Technical University of Denmark4
Department of Applied Mathematics and Computer Science, Technical University of Denmark5
Dynamical Systems, Department of Applied Mathematics and Computer Science, Technical University of Denmark6
Rush University7
Tel Aviv University8
University of California at San Diego9
Stroke affects millions each year. Post-stroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment.
Here we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents, to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds.
Thus, our understanding of post-stroke edema needs to be revised and these findings could provide a conceptual basis for development of alternative treatment strategies.
Language: | English |
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Publisher: | American Association for the Advancement of Science |
Year: | 2020 |
Pages: | eaax7171-eaax7171 |
ISSN: | 10959203 and 00368075 |
Types: | Journal article |
DOI: | 10.1126/science.aax7171 |
ORCIDs: | 0000-0001-5876-5397 , 0000-0002-9020-3746 , 0000-0001-6128-5757 , 0000-0002-4842-5126 , 0000-0003-3726-0781 , 0000-0002-2295-8637 , 0000-0002-2577-6783 , 0000-0002-5954-8957 , 0000-0003-2083-0901 , 0000-0001-9658-2954 , Martens, Erik Andreas , 0000-0002-4036-8729 , 0000-0002-4042-214X , 0000-0001-9797-4722 , 0000-0003-3806-6905 , 0000-0003-4208-0005 , 0000-0002-9254-5360 and Hjorth, Poul G. |