Journal article
Thyroglobulin as a marker of iodine nutrition status in the general population
Objective: The iodine status of a population is traditionally evaluated by either urinary iodine (UT) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population.
Methods: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography.
Results: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the Suggested reference limit (40 mu g/l) decreased from 11.3 to 3.7%, (P
Language: | English |
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Publisher: | European Federation of Endocrine Societies |
Year: | 2009 |
Pages: | 475-481 |
ISSN: | 1479683x and 08044643 |
Types: | Journal article |
DOI: | 10.1530/EJE-09-0262 |