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Journal article

Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa

By Marvig, Rasmus Lykke1; Søndergaard, Mette S. R.1,2,3; Pedersen, Søren Damkiær1,4; Høiby, Niels5; Johansen, Helle Krogh5; Molin, Søren1,4,6,7; Jelsbak, Lars1,4

From

Department of Systems Biology, Technical University of Denmark1

National Food Institute, Technical University of Denmark2

Division of Food Microbiology, National Food Institute, Technical University of Denmark3

Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark4

Copenhagen University Hospital Herlev and Gentofte5

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark6

Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark7

The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

Language: English
Publisher: American Society for Microbiology
Year: 2012
Pages: 4519-4521
ISSN: 10986596 , 00664804 and 10706283
Types: Journal article
DOI: 10.1128/AAC.00630-12
ORCIDs: Marvig, Rasmus Lykke , Søndergaard, Mette S. R. , Molin, Søren , Jelsbak, Lars and 0000-0002-1347-725X
Keywords

Anti-Bacterial Agents Azithromycin Cystic Fibrosis Drug Resistance, Bacterial Humans Mechanisms of Resistance Microbial Sensitivity Tests Mutation Point Mutation Pseudomonas Infections Pseudomonas aeruginosa RNA, Bacterial RNA, Ribosomal, 23S

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