Journal article
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism
Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities.
Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes.
Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
Language: | English |
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Publisher: | American Association for the Advancement of Science |
Year: | 2012 |
Pages: | 1099-1103 |
ISSN: | 10959203 and 00368075 |
Types: | Journal article |
DOI: | 10.1126/science.1206871 |
ORCIDs: | Jarmer, Hanne and Rasmussen, Simon |
Adaptation, Physiological Algorithms Bacillus subtilis Bacillus subtilis/genetics Bacterial Proteins Bacterial Proteins/metabolism Computer Simulation Data Interpretation, Statistical Gene Expression Regulation, Bacterial Gene Regulatory Networks Genome, Bacterial Glucose Glucose/metabolism Malates Malates/metabolism Metabolic Networks and Pathways Metabolic Networks and Pathways/genetics Metabolome Metabolomics Models, Biological Operon Promoter Regions, Genetic Transcription Factors Transcription Factors/metabolism Transcription, Genetic malic acid