Journal article
Increased lipids in non-lipogenic tissues are indicators of the severity of type 2 diabetes in mice
We hypothesised that the molecular changes triggered in type 2 diabetes might cause phenotypic changes in the lipid fraction of tissues. We compared tissue lipid profiles of inbred lean B6-Bom with those of the obese B6-ob/ob and diabetic BKS-db/db mice and found that genetically diabetic mice significantly accumulate fat (especially monounsaturated fatty acids, MUFA) in non-lipogenic tissues such as the eye (MUFA, 2-fold), skeletal muscle (MUFA, 13-fold) and pancreas (MUFA, 16-fold).
In contrast, the B6-ob/ob mice which manifest a milder form of type 2 diabetes use the liver as their predominant lipid depot (MUFA 91-fold increase, as compared to lean mice values). The lipids in the BKS-db/db skeletal muscle and pancreas were also significantly enriched with linoleic acid (LA, (9-fold and 6-fold, respectively); and alpha-linolenic acid (ALA, 8.5-fold and 8-fold, respectively).
MUFA, LA and ALA accumulation in the non-lipogenic tissues of BKS-db/db mice was associated with reduced liver stearoyl-CoA desaturase- I expression.
Language: | English |
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Year: | 2007 |
Pages: | 9-18 |
ISSN: | 09523278 and 15322823 |
Types: | Journal article |
DOI: | 10.1016/j.plefa.2006.09.002 |
ORCIDs: | 0000-0001-7360-7418 |
Adipose Tissue Animals Biomarkers Diabetes Mellitus, Type 2 Down-Regulation Eye Fatty Acids, Unsaturated Former Faculty of Pharmaceutical Sciences Gene Expression Regulation Lipid Metabolism Liver Male Mice Mice, Obese Muscle, Skeletal Pancreas Phospholipids Stearoyl-CoA Desaturase Triglycerides