Conference paper · Journal article
Glucose response to fast- And long-acting insulin in people with type 2 diabetes
In type 2 diabetes (T2D), injections with long-acting insulin can become necessary to regulate blood glucose and avoid long-term complications. However, finding a safe and effective insulin dose, a process known as titration, is both challenging and time demanding. In this paper, we propose a new method for safe and rapid identification of a personalized insulin dose with long-acting insulin through short-term use of fast-acting insulin in an artificial pancreas (AP).
To illustrate this novel concept, we simulate our method by modelling the glucose response to fast-and long-acting insulin in people with T2D. We apply a simple control-algorithm for the AP to adjust the insulin infusion rate during fasting periods. In this case-study, we simulate an insulin naïve T2D patient on AP treatment for one week, gradually adjusting the insulin infusion rate.
After one week, we convert the insulin infusion rate, unit-to-unit, to a daily injection of long-acting insulin. We compare our method to titration with the standard of care 2-0-2 algorithm. Our simulations indicate that we can reduce the titration period from five weeks to a single week, whilst easing the burden on the patient.
Language: | English |
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Year: | 2021 |
Pages: | 496-501 |
Proceedings: | 11<sup>th</sup> IFAC Symposium on Biological and Medical Systems |
ISSN: | 24058963 and 24058971 |
Types: | Conference paper and Journal article |
DOI: | 10.1016/j.ifacol.2021.10.305 |
ORCIDs: | Jørgensen, John Bagterp |