Journal article
Improved methods to determine radionuclidic purity of F-18 compounds
Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd.
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Language: | English |
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Year: | 2012 |
Pages: | 430-437 |
ISSN: | 18729800 and 09698043 |
Types: | Journal article |
DOI: | 10.1016/j.apradiso.2011.10.012 |
ORCIDs: | Jensen, Mikael |