Journal article
The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens
Washington University St. Louis1
Department of Systems Biology, Technical University of Denmark2
Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark3
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5
CFB - Core Flow, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark6
From Farm to Clinic?Soil organisms have long been assumed to be an important source of antibiotic resistance genes, in part because of antibiotic-treated livestock and in part because of the natural ecology of antibiotic production in the soil. Forsberg et al. (p. 1107) developed a metagenomic protocol to assemble short-read sequence data after antibiotic selection experiments, using 12 different drugs in all antibiotic classes, and compared antibiotic resistance gene sequences between soil bacteria and clinically occurring pathogens.
Sixteen sequences, representing seven gene products, were discovered in farmland soil bacteria within long stretches of perfect nucleotide identity with pathogenic proteobacteria.
Language: | English |
---|---|
Publisher: | American Association for the Advancement of Science |
Year: | 2012 |
Pages: | 1107-1111 |
ISSN: | 10959203 and 00368075 |
Types: | Journal article |
DOI: | 10.1126/science.1220761 |
ORCIDs: | Sommer, Morten O. A. |