Journal article · Conference paper
Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours : Production and dosimetric aspects of the Auger emitter Co-58m
Odense University Hospital1
Biomedical Tracers, Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark2
Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark3
Risø National Laboratory for Sustainable Energy, Technical University of Denmark4
Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo.
The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.
| Language: | English |
|---|---|
| Publisher: | American Association of Physicists in Medicine |
| Year: | 2011 |
| Pages: | 4535-41 |
| Proceedings: | 23rd Annual Congress of the European Association of Nuclear Medicine |
| ISSN: | 24734209 and 00942405 |
| Types: | Journal article and Conference paper |
| DOI: | 10.1118/1.3608905 |
| ORCIDs: | Elema, Dennis Ringkjøbing and Jensen, Mikael |
Auger electrons Biological tissues Biomedical materials Cancer Cellular biophysics Co-58m Cobalt Cyclotrons Dosimetry Ground states Impurities Patient treatment Pharmaceuticals Radioisotopes Radionuclide therapy SDG 3 - Good Health and Well-being Tumours
Auger electron emission Biomaterials Cell nucleus Cell processes Cobalt Radioisotopes Co‐58m Dosimetry/exposure assessment Electron radiation effects Humans Iron Isotopes Monte Carlo methods Neoplasms Radiometry Radiopharmaceuticals Radiotherapy Dosage Therapeutics biological tissues biomedical materials cancer cellular biophysics cobalt cyclotrons dosimetry ground states impurities patient treatment pharmaceuticals radioisotopes radionuclide therapy tumours
