Journal article
Response to Comment on "Positive Selection of Tyrosine Loss in Metazoan Evolution"
Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation.
We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.
Language: | English |
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Publisher: | American Association for the Advancement of Science |
Year: | 2011 |
Pages: | 917-917 |
ISSN: | 10959203 and 00368075 |
Types: | Journal article |
DOI: | 10.1126/science.1188535 |
ORCIDs: | Schoof, Erwin |