Journal article
A systematic framework for design of process monitoring and control (PAT) systems for crystallization processes
Department of Chemical and Biochemical Engineering, Technical University of Denmark1
Computer Aided Process Engineering Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark3
A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations.The systematic design framework contains a generic crystallizer modelling toolbox, a tool for generation of the supersaturation set-point for supersaturation control, as well as a tool for design of a process monitoring and control system (also called Process Analytical Technology (PAT) system).
This systematic design allows one to generate the necessary problem-chemical system specific model, the necessary supersaturation set-point as well as a PAT system design including implementation of monitoring tools and control strategies in order to produce the desired target product properties notably crystal size distribution (CSD) and shape for a wide range of crystallization processes.
Application of the framework is highlighted through a case study involving the design of a monitoring and control system for a potassium dihydrogen phosphate (KDP) crystallization process, where also the one-dimensional CSD and two-dimensional CSD modelling features are highlighted.
Language: | English |
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Year: | 2013 |
Pages: | 8-23 |
ISSN: | 18734375 and 00981354 |
Types: | Journal article |
DOI: | 10.1016/j.compchemeng.2013.03.003 |
ORCIDs: | Sin, Gürkan and Gernaey, Krist |