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Journal article

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

By Wu, Peng1,2; Cohrt, Anders Emil O'Hanlon1,2; Petersen, Rico1,2; Morgentin, Rémy3; Lemoine, Hugues3; Roche, Carine3; Willaume, Anthony3; Clausen, Mads Hartvig1,2; Nielsen, Thomas Eiland1,2

From

Organic Chemistry, Department of Chemistry, Technical University of Denmark1

Department of Chemistry, Technical University of Denmark2

EDELRIS3

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

Language: English
Publisher: The Royal Society of Chemistry
Year: 2016
Pages: 6947-6950
ISSN: 14770539 and 14770520
Types: Journal article
DOI: 10.1039/c6ob01148a
ORCIDs: Wu, Peng and Clausen, Mads Hartvig

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