Journal article
Synthesis of branched and linear 1,4-linked galactan oligosaccharides
We report the synthesis of linear and branched (1→4)-D-galactans. Four tetra- and one pentasaccharide were accessed by adopting a procedure of regioselective ring opening of a 4,6-O-naphthylidene protecting group followed by glycosylation using phenyl thioglycoside donros. The binding of the linear pentasaccharide with galectin-3 is also investigated by determination of a co-crystal structure.
The binding of the (1→4)-linked galactan to Gal-3 highlights oligosaccharides of pectic galactan, which is abundant in the human diet, as putative Gal-3 ligands.
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2018 |
Pages: | 1157-1162 |
ISSN: | 14770539 and 14770520 |
Types: | Journal article |
DOI: | 10.1039/C7OB03035E |
ORCIDs: | Gotfredsen, Charlotte Held , Clausen, Mads Hartvig Hartvig , 0000-0002-5795-1320 , 0000-0002-9388-0873 and 0000-0002-0098-8560 |