Journal article · Preprint article
Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor
Department of Physics, Technical University of Denmark1
Danish Research Centre for Magnetic Resonance2
Magnetic Resonance by Optics, Magnetic Resonance, Department of Health Technology, Technical University of Denmark3
Center for Macroscopic Quantum States, Department of Physics, Technical University of Denmark4
Quantum Physics and Information Technology, Department of Physics, Technical University of Denmark5
University of Copenhagen6
Department of Health Technology, Technical University of Denmark7
Magnetic Resonance, Department of Health Technology, Technical University of Denmark8
Neurophysics, Magnetic Resonance, Department of Health Technology, Technical University of Denmark9
Jagiellonian University in Kraków10
CNRS11
Leipzig University12
...and 2 moreThe ability to perform noninvasive and non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors.
These have many disadvantages in terms of high cost, flexibility and limited portability as well as poor spatial and temporal resolution. In this work we demonstrate an alternative technique for detecting magnetic fields generated by the current from action potentials in living tissue using nitrogen vacancy centres in diamond.
With 50 pT/Hz sensitivity, we show the first measurements of magnetic sensing from mammalian tissue with a diamond sensor using mouse muscle optogenetically activated with blue light. We show these proof of principle measurements can be performed in an ordinary, unshielded lab environment and that the signal can be easily recovered by digital signal processing techniques.
Although as yet uncompetitive with probe electrophysiology in terms of sensitivity, we demonstrate the feasibility of sensing action potentials via magnetic field in mammals using a diamond quantum sensor, as a step towards microscopic imaging of electrical activity in a biological sample using nitrogen vacancy centres in diamond.
Language: | English |
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Publisher: | Nature Publishing Group UK |
Year: | 2021 |
Pages: | 2412 |
ISSN: | 20452322 |
Types: | Journal article and Preprint article |
DOI: | 10.1038/s41598-021-81828-x |
ORCIDs: | Troise, Luca , Olsson, Christoffer , Thielscher, Axel , Berg-Sørensen, Kirstine , Huck, Alexander , Andersen, Ulrik Lund and 0000-0002-9189-3574 |