Journal article
Characterization of four new antifungal yanuthones from Aspergillus niger
Department of Systems Biology, Technical University of Denmark1
Department of Chemistry, Technical University of Denmark2
Organic Chemistry, Department of Chemistry, Technical University of Denmark3
Fungal Physiology and Biotechnology, Department of Systems Biology, Technical University of Denmark4
Metabolomics Platform, Department of Systems Biology, Technical University of Denmark5
Eucaryotic Molecular Cell Biology, Department of Systems Biology, Technical University of Denmark6
Fermentation Platform, Department of Systems Biology, Technical University of Denmark7
Four new yanuthone analogs (1–4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with 13C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1–3)) and a class II yanuthone, which was named yanuthone X2 (4).
The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
Language: | English |
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Publisher: | Nature Publishing Group UK |
Year: | 2015 |
Pages: | 201-205 |
Journal subtitle: | Official Journal of the Society for Actinomycetes, Japan |
ISSN: | 18811469 , 00218820 and 03682781 |
Types: | Journal article |
DOI: | 10.1038/ja.2014.130 |
ORCIDs: | Nielsen, Kristian Fog , Gotfredsen, Charlotte Held , Mortensen, Uffe Hasbro and Larsen, Thomas Ostenfeld |